- Abstract -

Alzheimer s Disease is usually sporadic, though in around 5% of cases mostly in younger age-groups- the disease is inherited in an autosomal dominant fashion. Mutations in genes coding for amyloid precursor protein (APP) and presenilin (PS1and PS2) produce a clinical picture of AD. Mechanisms leading to the commoner form of AD are incompletely understood. Numerous studies of the epidemiology of AD have been undertaken with the aims of social planning and identifying modifiable risk factors for the development of the disease. There were have been identifyied  possible risk factors and also protective factors for AD.

Key words: Alzheimer s disease, risk factor