Background. Selenium is
a trace element that acts as an important
antioxidative and anti-inflammatory agent. It has
been shown that serum selenium concentrations in
patients with rheumatoid arthritis are low, and
therefore anhance the inflammation of the joint soft
tissues.
Material and method. In
a prospective study, performed during 3 month, one
evaluated the therapeutical effects of the daily 200
mcg selenium doses, administered as a nutrient
supplement, in a trial of 45 patrients, aged from 45
to 75 years, followed-up ambulatory for rheumatoid
arthritis.
Serum selenium levels,
acute-phase reagents as well as some parameters
concerning the pain syndrome were evaluated
comparatively before and after the treatment. Serum
selenium levels were determined by atomic absorbtion
spectrophotometry.
Results and discussions.
The significant clinical effects due to the selenium
action consisted: the decrease of joint rest, and
the improving of psihycal activity. The favourable
evolution was also assessed by the decrease of
acute-phase reagents, by reducing the joint
inflammatory process.
Conclusions. Selenium
pharmacotherapy has certain beneficial effects in
patients with rheumatoid arthritis.
Key words. selenium,
pain relief, rheumatoid arthritis, acute-phase
reagents, therapeutic efficiency.